Korean J Nephrol.  1997 Mar;16(1):156-161.

A Case of Langerhan's Symbol 146/f "Times New Roman" Cell Histiocytosis with Diabetes Insipidus

• Lee YH
• Lee KB
• Kim YG
• Oh HY
• Kwon OJ
• Byun HS
• Lee HJ

Abstract

Central diabetes insipidus (CDI) is a clinical syndrome that result from a failure of the neurohypophyseal axis to produce or release a sufficient quantity of arginine vasopressin (AVP) to permit normal function of the urinary concentrating mechanism. Polyuria and polydipsia are the symptoms associated with CDI. The most common cause of CDI is idiopathic variety and head trauma, neurohypophyseal surgery, primary or metastatic brain tumors acount for most of the remaining cases. CDI in Langerhans cell histiocytosis (LCH) is thought to be to infiltration of the hypothalamus-neurohypophyseal system. We report a patient with CDI and LCH underwent water depriviation test, MR imaging of the pituitary-hypothalamic region, and VATS associated open lung biopsy.

MeSH Terms

Arginine Vasopressin
Axis, Cervical Vertebra
Biopsy
Brain Neoplasms
Craniocerebral Trauma
Diabetes Insipidus*
Diabetes Insipidus, Neurogenic
Histiocytosis*
Histiocytosis, Langerhans-Cell
Humans
Lung
Magnetic Resonance Imaging
Polydipsia
Polyuria
Thoracic Surgery, Video-Assisted
Arginine Vasopressin