Korean J Nephrol.  1997 Dec;16(4):788-792.

Minimal Change Nephrotic Syndrome Associated with Intraabdominal Liposarcoma

• Kim SW
• Choi EJ
• Song HC
• Park SM
• Kim YS
• Choi MH
• Kim JN
• Choi IB
• Kim W
• Bang BK

Abstract

We present a case of liposarcoma related with minimal change nephrotic syndrome. A 49-year-old woman was admitted due to generalized edema and a palpable mass at epigastric area. Her laboratory data were as follows : serum creatinine 0.6mg/dl, BUN 7mg/dl, serum total protein 3.6g/dl(albumin 0.6 g/dl) serum total cholesterol 299mg/dl, 24 hour-urine protein 5.1g. A CT scan of the abdomen revealed huge adult head sized mass(15X10X15cm) consisted with mixed pattern of well enhancing solid, cystic and fat portion which is located between the liver and the stomach. A kidney biopsy showed minimal change nephropathy. At explo-laparostomy the tumor was well differentiated liposarcoma. After operation and steroid therapy, her proteinuria and hypoalbuminemia were a little improved. And then radiation therapy(daily 180 cGy, 5 fx/wk, upto 5040cGy/28 fx/42 day) was done. Complete remission of liposarcoma was followed by regression of the nephrotic syndrome. After radiation therapy, her laboratory data were serum total protein 6.7g/dl (albumin 4.3g/dl), total cholesterol 170mg/dl, 24 hour-urine protein 0.3g. She has been maintained complete remission of the nephrotic syndrome by steroid maintenance dose.

Keyword

Minimal change nephrotic syndrome; Liposarcoma

MeSH Terms

Abdomen
Adult
Biopsy
Cholesterol
Creatinine
Edema
Female
Head
Humans
Hypoalbuminemia
Kidney
Liposarcoma*
Liver
Middle Aged
Nephrosis, Lipoid*
Nephrotic Syndrome
Proteinuria
Stomach
Tomography, X-Ray Computed
Cholesterol
Creatinine