Yonsei Med J.  1981 Dec;22(2):133-136. 10.3349/ymj.1981.22.2.133.

HLA Type in Minimal Lesion Nephrotic Syndrome (MLNS) in Childhood

• Kim PK
• Yun DJ

• KMID: 934621
• DOI: http://doi.org/10.3349/ymj.1981.22.2.133

Abstract

Association of HLA antigens with certain diseases provide insights into genetically determined susceptibility to disease. Although nephrotic syndrome is one of the commonest diseases, it is poorly understood. A group of 57 patients suffering from a minimal lesion nephrotic syndrome (33 patients) and mesangioproliferative glomerulonephritis (24 patients) was studied for immunologic markers. The incidence of HLA-A w 24 is significantly greater in the minimal lesion nephrotic syndrome patients than in controls (18.7% in patients, 0% in controls, p < 0.01). This report fails to show a high incidence of specific HLA antigen in mesangioproliferative glomerulonephritis patients. We believe that the high incidence of HLA-Aw 24 in minimal lesion nephrotic syndrome is indicative of a congenital predisposition to nephrotic syndrome.

Keyword

Minimal lesion nephrotic syndrome; Human Lymphocytes Antigen

MeSH Terms

Glomerulonephritis/immunology
HLA Antigens/analysis*
Human
Nephrosis, Lipoid/immunology*