Korean J Nephrol.  2008 Jan;27(1):55-61.

Contrast-induced Nephropathy in Patients Undergoing Percutaneous Coronary Angiography and its Clinical Characteristics

• Choi W
• Lim HM
• Won HJ
• Park HK
• Lee BS
• Ahn HS
• Joo HW
• Kim SH
• Park WD

Abstract

PURPOSE: Contrast media-induced nephropathy (CIN) following coronary angiography is associated with an increased mortality and morbidity. We investigated the incidence of nephrotoxicity, clinical characteristics, laboratory characteristics and risk factors of CIN in patients undergoing coronary angiography.
METHODS
We retrospectively evaluated the medical records of 555 patients who had undergone coronary angiography at the Sanggye Paik Hospital, from January 2004 to December 2005. We defined CIN as any increase in the creatinine value of more than 0.5 mg/dL or 50% of baseline value.
RESULTS
Among 555 patients, CIN developed in 10 of 48 patients (20.8%) with renal insufficiency (serum creatinine > or =1.4 mg/dL) and in 7 of 507 patients (1.4%) without renal insufficiency (p<0.001). Decreased renal function, congestive heart failure, higher baseline uric acid, lower baseline albumin and age > or =65 years were the significant predictors of CIN. There were no statistical differences in contrast type and volume according to the development of CIN.
CONCLUSION
Our data supported the assumption that renal insufficiency, congestive heart failure, hyperuricemia and anemia may be the risk factors of developing CIN.

Keyword

Contrast media; Coronary angiography; Renal insufficiency; Uric acid

MeSH Terms

Anemia
Contrast Media
Coronary Angiography
Creatinine
Heart Failure
Humans
Hyperuricemia
Incidence
Medical Records
Renal Insufficiency
Retrospective Studies
Risk Factors
Uric Acid
Contrast Media
Creatinine
Uric Acid