Korean J Nephrol.
2008 Mar;27(2):248-250.
Acute Renal Failure Complicated by Valaciclovir in a Patient with IgA Nephropathy
- Affiliations
-
- 1Division of Nephrology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea. yjkwon@korea.ac.kr
- 2Department of Internal Medicine, Wonkwang University, Seoul, Korea.
Abstract
- Valaciclovir is L-valyl ester of acyclovir which has the antiviral effect against herpes zoster virus and Cytomegalovirus. Its adverse effects were reported as nephrotoxicity and neurotoxicity. Although the mechanism of nephrotoxicity of valaciclovir is indeterminate, several hypotheses such as obstructive uropathy and interstitial nephritis have been suggested. We experienced a 54-year-old female patient with IgA nephropathy who developed acute renal failure after taking valaciclovir. She did not develop either central neuropathy or respiratory muscle weakness. The serum creatinine was normalized after 6 days by withdrawal of valaciclovir and hydration. When we use valaciclovir in the elderly or patients with preexisting renal disease, we should monitor the renal function carefully.
Keyword
MeSH Terms
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Acute Kidney Injury
Acyclovir
Aged
Creatinine
Cytomegalovirus
Female
Glomerulonephritis, IGA
Herpesvirus 3, Human
Humans
Immunoglobulin A
Middle Aged
Nephritis, Interstitial
Organothiophosphorus Compounds
Renal Insufficiency
Respiratory Muscles
Valine
Acyclovir
Creatinine
Immunoglobulin A
Organothiophosphorus Compounds
Valine
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