Change of Body Composition Analyzed by Bioelectrical Impedance Analysis (BIA) in Renal Transplant Recipients

Hur, In Kyong; Lee, Eun Young; Cho, Ji Hyung; Choi, Ji Young; Seo, Jung Joo; Park, Sun Hee; Kim, Chan Duck; Kim, Yong Lim

Abstract

PURPOSE
To investigate the changes of body fluid status after kidney transplantation (KT) and to find out the associated factors.
METHODS
Forty-five patients who had received KT were classified into hemodialysis (n=32), peritoneal dialysis (n=5), and preemptive (n=8) groups by dialysis modality. %TBW, %ECF, %ICF, and edema index which were examined by bioelectrical impedance analysis as well as clinical parameters were prospectively measured before KT and 1st month, 3rd month, 6th month after KT.
RESULTS
Before KT, there were no significant differences in all of the parameters listed above among the three groups. Mean %TBW and %ICF were not different compared to those of before KT. In contrast, mean %ECF markedly decreased within 1st month (before KT 21.13+/-3.04 L/kg, 1st month 20.03+/-2.37 L/kg, 3rd month 19.61+/-2.18 L/kg, 6th month 18.32+/-5.02 L/kg: p=0.007, p<0.001, p=0.001, respectively). Edema index also decreased from 1st month (1st month 0.354+/-0.014, 3rd month 0.352+/-0.011, 6th month 0.348+/-0.014: p=0.016, p=0.012, respectively). Only edema index was higher at 1st and 3rd month in hemodialysis group. Serum creatinine and 24 hour urine total protein were positively correlated with %ECF at 1st and 3rd month, and with %TBW at 3rd month.
CONCLUSION
The recovery of body water distribution after KT starts with reduction of ECF within the 1st month. Serum creatinine and proteinuria are related to the recovery. No significant difference according to dialysis modality was found. Further study with larger sample size is necessary to confirm these findings.