Korean J Nephrol.
2010 Sep;29(5):644-649.
Biopsy-Proven Immune Complex Glomerulonephritis Associated with Sunitinib in a Patient with a Gastrointestinal Stromal Tumor
- Affiliations
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- 1Department of Internal Medicine, Eulji Hospital, Daejeon, Korea.
- 2Department of Internal Medicine, Seoul National University College of Medicine, Korea. khoh@snu.ac.kr
- 3Department of Pathology, Seoul National University College of Medicine, Korea.
Abstract
- Sunitinib, a multi-targeted tyrosine kinase inhibitor, is used for the treatment of renal cell carcinoma and gastrointestinal stromal tumors. Many adverse effects associated with sunitinib, including hypertension, proteinuria, and thrombotic microangiopathy, have been reported; however, the other forms of glomerulonephritis are very rare. We report a case of biopsy-confirmed immune complex glomerulonephritis in a patient with a gastrointestinal tumor who received sunitinib treatment. The proteinuria subsided partially after sunitinib was discontinued, but when the drug was reintroduced, it recurred.
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