Korean J Nephrol.  2010 Sep;29(5):623-627.

A Case of Nephrotic Syndrome with Acute Renal Failure Induced by Tramadol HCl/Acetaminophen

• Son YK
• Nam YH
• Lee SM
• Kim HI
• An WS
• Kim SE
• Kim KH
• Rha SH

Abstract

Analgesics are used commonly because of their beneficial effects on various disease processes and pain control, and so the population of patients who are at risk for adverse effects of these drugs is rapidly expanding. A number of renal problems have been associated with the use of these drugs, including electrolyte imbalance, acute renal failure, nephrotic syndrome, and interstitial nephritis. We experienced a 65-year-old female patient who developed general edema and oliguria for 4 days and diagnosed as focal segmental glomerulosclerosis with interstitial nephritis. She had taken tramadol HCl/acetaminophen (Ultracet(R)) for 15 days before admission. Renal biopsy revealed that focal tubular atropy, focal interstitial fibrosis and evidence of diffuse inflammatory cell infiltrations. Tramadol HCl/acetaminophen (Ultracet(R)) was discontinued on admission because of the likelihood the renal disease was drug-related and the patient improved after discontinuation of this drug without remained renal damage. This case suggests that Ultracet(R) must be an agent that causes nephrotic syndrome with acute renal failure. Therefore clinicians should use it with caution in high risk patients.

Keyword

Analgesics; Nephrotic syndrome; Acute renal failure

MeSH Terms

Acute Kidney Injury
Aged
Analgesics
Biopsy
Edema
Female
Fibrosis
Glomerulosclerosis, Focal Segmental
Humans
Nephritis, Interstitial
Nephrotic Syndrome
Oliguria
Tramadol
Analgesics
Glomerulosclerosis, Focal Segmental
Tramadol