Korean J Med.  2002 Aug;63(2):209-213.

A case of minimal change glomerulopathy without interstitial nephritis induced by non-opiate analgesics

• Li JH
• Shim H
• Yeom JJ
• Lee MS
• Park BH
• Oh SK
• Kim NH
• Park MR
• Ahn SH
• Song JH

Abstract

The use of nonsteroidal antiinflammatory drugs (NSAIDs) can be complicated by severe forms of renal dysfunction. These include fluid and electrolyte abnormalities, acute renal insufficiency due to alteration in renal hemodynamics, or interstitial nephritis and proteinuria secondary to glomerular pathology, which has the histologic characteristics of minimal change glomerulopathy (MCG). While NSAID-induced nephrotic syndrome characteristically consists of MCG with interstitial nephritis, which is the most common clinical manifestation, it rarely consists of MCG without interstitial nephritis, which has been reported in a handful of patients who took fenoprofen, ibuprofen, sulindac, diclofenac, or zomepirac. We experienced a 66-year-old female patient who presented with low serum albumin, proteinuria and generalized edema and received Geworin for about 2 year before developing symptoms. She histologically had MCG without interstitial nephritis and achieved a complete remission thirty-fifth days after discontinuing the drug. A cause-and-effect relationship of this disease to Geworin administration is strongly suggested by the resolution of the proteinuria after the drug was stopped and by no evidence of any impairment in renal function after twenty eight months of follow-up.

Keyword

Antipyrine; Anti-inflammatory Agents; Non-Steroidal; Nephritis; Interstitial; Nephrotic syndrome

MeSH Terms

Acute Kidney Injury
Aged
Analgesics*
Anti-Inflammatory Agents
Antipyrine
Diclofenac
Edema
Female
Fenoprofen
Follow-Up Studies
Hand
Hemodynamics
Humans
Ibuprofen
Nephritis
Nephritis, Interstitial*
Nephrosis, Lipoid*
Nephrotic Syndrome
Pathology
Proteinuria
Serum Albumin
Sulindac
Analgesics
Anti-Inflammatory Agents
Antipyrine
Diclofenac
Fenoprofen
Ibuprofen
Serum Albumin
Sulindac