Korean J Nephrol.  2011 Jul;30(4):409-413.

Adult Onset Still's Disease Developed in a Patient with Membranous Nephropathy Treated with Immunosuppressive Agent

• Kang HJ
• Kim JM
• Park SY
• Lee SY
• Kim KH
• Kim SE
• Son YK
• An WS

Abstract

Adult onset Still's disease (AOSD) is a rare systemic inflammatory disease characterized by high spiking fever, leukocytosis, high serum ferritin, salmon-colored rash, arthritis, lymphadenopathy, and hepatosplenomegaly. The etiology of AOSD is obscure. AOSD is diagnosed after exclusion of infection, malignancy and other connective tissue diseases. A 53-year-old female patient with membranous nephropathy was admitted with high fever and leukocytosis. She was taking immunosuppressive agents with low dose steroid and cyclosporine to control of proteinuria caused by membranous nephropathy. She was initially treated with antibiotics, antiviral agent and antifungal agent to control of hidden infection. High spiking fever was sustained for 2 weeks and controlled after hydrocortisone treatment. AOSD was diagnosed according to the criteria of Yamaguchi. It should be considered that AOSD is a cause of high fever in patients treated with immunosuppressive agents.

Keyword

Adult onset still's disease; Membranous nephropathy; Immunosuppressive agent

MeSH Terms

Adult
Anti-Bacterial Agents
Arthritis
Connective Tissue Diseases
Cyclosporine
Exanthema
Female
Ferritins
Fever
Glomerulonephritis, Membranous
Humans
Hydrocortisone
Immunosuppressive Agents
Leukocytosis
Lymphatic Diseases
Middle Aged
Proteinuria
Still's Disease, Adult-Onset
Anti-Bacterial Agents
Cyclosporine
Ferritins
Hydrocortisone
Immunosuppressive Agents