Korean J Hematol.  2007 Mar;42(1):67-70. 10.5045/kjh.2007.42.1.67.

A Case of Heparin Induced Thrombocytopenia with Circulating Anti-PF4/Heparin Antibody

• Lee Y
• Kim J
• Song J
• Song KS

• KMID: 2252272
• DOI: http://doi.org/10.5045/kjh.2007.42.1.67

Abstract

Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. Circulating anti-PF4/heaprin antibody (IgG, IgA and IgM) was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France) in a 61-yearold man with coronary artery disease and dyspnea on exercise. He had undergone a coronoary angiography using 2,000 unit of heparin before a procedure. On admission, laboratory testing revealed a platelet count of 296x10(9)/L and aPTT (activated partial thromboplastin time) of 38.1 sec. The fall in the platelet count was progressive, resulting in 42% and 53% of platelet counts on the 6th and 12th days after intravenous heparin administration, respectively. He was discharged after coronary artery bypass graft. On discharge, platelet count was normalized to be 212x10(9)/L. On the 7th day after dischage, anti-PF4/heaprin antibody was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France).

Keyword

Heparin induced thrombocytopenia; Anti-PF4/heaprin antibody; ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France)

MeSH Terms

Angiography
Antibodies
Coronary Artery Bypass
Coronary Artery Disease
Dyspnea
Enzyme-Linked Immunosorbent Assay
Heparin*
Immunoglobulin A
Platelet Activation
Platelet Count
Thrombocytopenia*
Thromboplastin
Transplants
Antibodies
Heparin
Immunoglobulin A
Thromboplastin

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