Korean J Lab Med.  2006 Oct;26(5):334-337. 10.3343/kjlm.2006.26.5.334.

Two Cases of Heparin-Induced Thrombocytopenia Diagnosed by Particle Gel Immunoassay

• Song KS
• Chang SH
• Suh JS

• KMID: 2238847
• DOI: http://doi.org/10.3343/kjlm.2006.26.5.334

Abstract

Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy. It represents initially as thrombocytopenia and is associated with venous or arterial thrombosis. It has been reported that platelet factor 4/heparin complex antibody plays an important role in the pathogenesis of HIT. Patients on hemodialysis have a high risk of developing HIT because heparin is administrated in hemodialysis as anticoagulant. Thrombocytopenia usually occurs 5 to 10 days after the onset of administration, but occasionally, it may occur rapidly in patients who have preformed antibodies from recent heparin use. We report here 2 cases of HIT with platelet factor 4-heparin reactive antibody in hemodialysis patients.

Keyword

Heparin-induced thrombocytopenia; Platelet factor 4-heparin reactive antibody; Hemodialysis

MeSH Terms

Antibodies
Blood Platelets
Heparin
Humans
Immunoassay*
Renal Dialysis
Thrombocytopenia*
Thrombosis
Antibodies
Heparin

Figure

• 

  Fig. 1. Time course of platelet count in two patients with heparin-induced thrombocytopenia. A: Case 1, B: Case 2.

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  Fig. 2. The results of particle gel immunoassay. Serum samples of two patients showed positive reactions.

Reference

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