Korean J Lab Med.
2006 Oct;26(5):334-337. 10.3343/kjlm.2006.26.5.334.
Two Cases of Heparin-Induced Thrombocytopenia Diagnosed by Particle Gel Immunoassay
- Affiliations
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- 1Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea. docsong@hanmail.net
- 2Department of Laboratory Medicine, Fatima Hospital, Daegu, Korea.
- KMID: 2238847
- DOI: http://doi.org/10.3343/kjlm.2006.26.5.334
Abstract
- Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy. It represents initially as thrombocytopenia and is associated with venous or arterial thrombosis. It has been reported that platelet factor 4/heparin complex antibody plays an important role in the pathogenesis of HIT. Patients on hemodialysis have a high risk of developing HIT because heparin is administrated in hemodialysis as anticoagulant. Thrombocytopenia usually occurs 5 to 10 days after the onset of administration, but occasionally, it may occur rapidly in patients who have preformed antibodies from recent heparin use. We report here 2 cases of HIT with platelet factor 4-heparin reactive antibody in hemodialysis patients.
MeSH Terms
Figure
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Fig. 1. Time course of platelet count in two patients with heparin-induced thrombocytopenia. A: Case 1, B: Case 2.
Fig. 2. The results of particle gel immunoassay. Serum samples of two patients showed positive reactions.