Korean J Hematol.  2009 Dec;44(4):268-272. 10.5045/kjh.2009.44.4.268.

A Case of Solitary Involved NK-T Cell Lymphoma on the Gallbladder

• Ko HJ
• Yang MY
• Kim HJ
• Yun JA
• Kim HJ
• Lee SC
• Bae SB
• Kim CK
• Lee NS
• Park SK
• Lee KT
• Won JH
• Hong DS
• Park HS
• Kim HK

• KMID: 2252108
• DOI: http://doi.org/10.5045/kjh.2009.44.4.268

Abstract

Extranodal NK-T cell lymphoma is a subtype of non-Hodgkin's lymphoma (NHL) and this most commonly affects the nasal and paranasal cavities. Primary lymphoma of the gallbladder is extremely rare and solitary relapsed extranodal NK-T cell lymphoma of the gallbladder has not yet been reported in Korea. We experienced a case of a solitary relapsed extranodal NK-T cell lymphoma of the gallbladder. One year earlier, a 55-year-old man was diagnosed with extranodal NK-T cell lymphoma of the anus, and he underwent six cycles of chemotherapy with CHOP (cyclophosphamide, adriamycin, vincristine and prednisone), and he achieved complete remission. The patient was admitted for right upper quadrant pain. Computed tomography (CT) performed on readmission revealed gallbladder wall thickening. Fluorodeoxyglucose-positron emission tomography (FDG-PET) showed hypermetabolic lesions along the gallbladder wall. The specimen obtained at cholecystectomy revealed CD3(+) and CD56(+) lymphoma, which is characteristic of NK-T cell lymphoma.

Keyword

Extranodal NK-T cell lymphoma; Gallbladder cancer; Non-Hodgkin's lymphoma

MeSH Terms

Anal Canal
Cholecystectomy
Doxorubicin
Gallbladder
Gallbladder Neoplasms
Humans
Korea
Lymphoma
Lymphoma, Non-Hodgkin
Middle Aged
Vincristine
Doxorubicin
Vincristine

Figure

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  Fig. 1. Dynamic abdomen-pelvic CT scans showed that the mucosal surface of gallbladder was irregularly thickened and its lamina layer was also enhanced.

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  Fig. 2. Focal hypermetabolism was observed in the upper and mid-body portion of the gallbladder on FDG-PET scan (p-SUV=9.7).

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  Fig. 3. Pathologic findings of gallbladder (A) The gallbladder was thickened diffusely and showed granular appearance. (B) An artery was infiltrated with lymphoma and destructed (H-E, ×100). And the lymphoma cells were stained strongly for (C) CD3 and (D) CD56 (Immunohistochemistry, ×200).

Reference

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