Korean J Hematol.  2010 Mar;45(1):58-61. 10.5045/kjh.2010.45.1.58.

Efficacy and safety of deferiprone (Ferriprox), an oral iron-chelating agent, in pediatric patients

  • 1Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea. cj@yuhs.ac
  • 2Department of Pediatrics, College of Medicine, Chonnam National University Medical School, Hwasun, Korea.
  • 3Department of Pediatrics, College of Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.
  • 4Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 5Department of Pediatrics, College of Medicine, University of Ulsan, Ulsan, Korea.
  • 6Department of Pediatrics, College of Medicine, Soonchunhyang University, Cheonan, Korea.


Iron overload is a predictable and life-threatening complication in patients dependent on the regular transfusion of RBCs. The aims of this study were to investigate the efficacy and safety of deferiprone in a variety of pediatric hematologic and/or oncologic patients with a high iron overload.
Seventeen patients (age: 1.1-20.4 years; median: 10.6 years) from 7 hospitals who were treated with deferiprone from 2006 to 2009 were enrolled in this study. Medical records of enrolled patients were reviewed retrospectively.
Serum ferritin levels were 4,677.8+/-1,130.9 microgram/L at baseline compared to 3,363.9+/-1,149.7 microgram/L at the end of deferiprone treatment (P=0.033). Only 1 patient developed neutropenia as a complication.
Deferiprone treatment is relatively safe for pediatric patients suffering from various hematologic and oncologic diseases that require RBC transfusions as part of treatment. However, the potential development of critical complications such as agranulocytosis and/or neutropenia remains a concern.


Deferiprone; Iron overload; Transfusion; Neutropenia

MeSH Terms

Iron Overload
Medical Records
Stress, Psychological


  • Fig. 1 Serum ferritin concentrations of all patients at baseline (■) versus end of study (▲). Compared to baseline, the decline in serum ferritin levels at the end of the study was statistically significant (P=0.033).


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