Korean J Med.  1997 Mar;52(3):334-341.

Lipoprotein(a) Levels Relate to Vascular Complications in Patients with Non-Insulin-Dependent Diabetes Mellitus(NIDDM)

• Kim SH
• Chai HB
• Park JY
• Min WK
• Kim WK
• Kim GS
• Lee KU

Abstract

OBJECTIVES
High serum Lp(a) concentration is associated with a high risk of coronary artery disease(CAD). This study was initiated to determine whether increased Lp(a) levels are associated with diabetic vascular complications in Korean patients with NIDDM.
METHODS
A total of 183 NDDM patients were studied cross-sectionally for the presence of various vascular complications. Lp(a) levels were measured by 1-step sandwich ELISA method.
RESULTS
The patients with overt proteinuria had higher Lp(a) levels than the patients with mormoalbuminuria or microalbuminuria(26.8mg/dl vs 13.8 mg/dl and 17.3mg/dl, p<0.05), The patients with proliferative retinopathy and/or those treated by photocoagulation had higher Lp(a) levels than those without retinopathy or those with background retinopathy(34.1mg/dl vs 13.3mg/dl and 16,9mg/dl, p<0.05), The Lp(a) levels were also higher in the patients with CAD than those without CAD(30.9mg/ dl vs 16.3mg/dl, p<0.05). Multiple logistic regression analysis revealed that high Lp(a) levels were independantly associated with CAD and severe diabetic retinopath3.
CONCLUSION
High Lp(a) levels are associated with CAD and proliferative retinopathy in Korean patients with NIDDM.

Keyword

Lp(a); NIDDM; Coronary artery disease; Diabetic retinopathy; Diabetic nephropathy

MeSH Terms

Coronary Artery Disease
Coronary Vessels
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Diabetic Nephropathies
Diabetic Retinopathy
Enzyme-Linked Immunosorbent Assay
Humans
Light Coagulation
Lipoprotein(a)*
Logistic Models
Proteinuria
Lipoprotein(a)