Korean J Med.
1999 Sep;57(3):380-384.
Rhabdomyolysis and localized myositis associated with amitiptyline overdose
- Affiliations
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- 1Department of Internal Medicine, Asan-Foundation Kangnung Hospital, Kangnung, Korea.
- 2Department of Diagnostic Radiology, Asan-Foundation Kangnung Hospital, Kangnung, Korea.
- 3Department of Orthopedic Surgery, Asan-Foundation Kangnung Hospital, Kangnung, Korea.
- 4Department of Diagnostic Pathology, Asan-Foundation Kangnung Hospital, Kangnung, Korea.
- 5Department of Nuclear Medicine, Asan-Foundation Kangnung Hospital, Kangnung, Korea.
Abstract
- Widespread use of amitriptyline in clinical practice has led to extensive knowledge of its therapeutic and toxic effects. In cases of amitriptyline overdose, delirium, arrhythmia, convulsion, and adult respiratory distress syndrome have been reported, but amitriptyline-associated rhabdomyolysis has been rarely reported in the literature. Several drugs are associated with myositis or myopathy, but amitriptyline-related myositis has not been reported. We describe a 40-year-old woman with rhabdomyolysis and localized myositis in left proximal thigh after she had taken 625mg of amitriptyline.
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