Korean J Biol Psychiatry.
2015 Nov;22(4):223-232. 10.0000/kjbp.2015.22.4.223.
The Correlation of Levels of Serum Lipid, Homocysteine, and Folate with Volumes of Hippocampus, Amygdala, Corpus Callosum, and Thickness of Entorhinal Cortex in Patients with Amnestic Mild Cognitive Impairment or Dementia of Alzheimer's Type
- Affiliations
-
- 1Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. npk@chol.com
- 2Department of Biomedical Engineering, and U-Health Care Research Center, Inje University, Gimhae, Korea.
- 3Department of Psychology, Inje University Haeundae Paik Hospital, Busan, Korea.
- 4Department of Radiology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
- KMID: 2251072
- DOI: http://doi.org/10.0000/kjbp.2015.22.4.223
Abstract
OBJECTIVES
In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type.
METHODS
The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis.
RESULTS
In patients with aMCI, old age (> 80) and APOE epsilon4 carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume.
CONCLUSIONS
Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.
MeSH Terms
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Alzheimer Disease
Amygdala*
Apolipoproteins
Apolipoproteins E
Brain
Cholesterol
Corpus Callosum*
Dementia*
Entorhinal Cortex*
Folic Acid*
Hippocampus*
Homocysteine*
Humans
Korea
Linear Models
Lipoproteins
Mild Cognitive Impairment*
Risk Factors
Apolipoproteins
Apolipoproteins E
Cholesterol
Folic Acid
Homocysteine
Lipoproteins
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