Korean J Biol Psychiatry.  2013 Sep;20(3):104-110.

A Prospective Study on an Association between Apolipoprotein E epsilon4 and Cognitive Change in Community-Dwelling Elders with Alzheimer's Disease

• Kang MS
• Moon SW

Abstract

OBJECTIVES
The aim of this study was to examine the prospective impact of the apolipoprotein E (APOE) epsilon4 on cognitive performance in the community-dwelling elderly individuals with Alzheimer's disease (AD).
METHODS
The total number of subjects was 30 (12 men and 18 women) who were diagnosed with AD from a Korean project of "Early Detection of Dementia". People aged 65-85 years were included in the analysis. The eight neuropsychological domains from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease (CERAD-K) were conducted to test subjects. They have been followed at 24-month intervals with the same assessments at each interval. Their cognitive performance at 2 year intervals was compared by the occurrence of the APOE epsilon4.
RESULTS
The impact of epsilon4 allele was significant in the Word List Memory Test (WLMT, F = 4.345, df = 1, p = 0.021) and Word List Recall Test (WLRT, F = 5.569, df = 1, p = 0.033).
CONCLUSIONS
The APOE epsilon4 allele was significantly correlated especially with verbal episodic memory domain in community-dwelling elders diagnosed with AD.

Keyword

Alzheimer's disease; Apolipoprotein E; CERAD-K; Prospective study

MeSH Terms

Aged
Alleles
Alzheimer Disease*
Apolipoproteins E
Apolipoproteins*
Humans
Male
Memory
Memory, Episodic
Prospective Studies*
Apolipoproteins
Apolipoproteins E