Korean J Psychopharmacol.  2011 Jan;22(1):49-56.

The Influence of Apolipoprotein E epsilon4 and Lipid Profile on Cognitive Function in Community-Dwelling Elders with Mild Cognitive Impairment

• Kim TH
• Moon SW

Abstract

OBJECTIVE
The aim of this study is to examine the relationship between lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-cholesterol), and low-density lipoprotein cholesterol (LDL-cholesterol) and cognitive function by the occurrence of the apolipoprotein E (APOE) epsilon4 in the community-dwelling elderly individuals with mild cognitive impairment (MCI).
METHODS
The total number of subjects was 203 (77 men and 126 women) who were diagnosed with MCI from a Korean project of "Early Detection of Dementia". Aged 65-85 years were included in this analysis. The eight neuropsychological domain from the Korean version of Consortium to Establish a Registry of Alzheimer's Disease neuropsychological test battery (CERAD-K, NP) were conducted to test subjects. The lipid profiles of all subjects were measured including TC, TG, HDL-cholesterol, and LDL-cholesterol levels and the correlation between the lipid levels and the neuropsychological test scores was analyzed by the occurrence of the APOE epsilon4.
RESULTS
There was significant correlation between HDL-C and Word List Recall Test (WLRT) of the neuropsychological test score in CERAD-K (NP) in the presence of APOE epsilon4 (WLRT/HDL-C: r=0.163, p<0.05).
CONCLUSION
The HDL-C level might be correlated with verbal episodic memory domain in CERAD-K (NP) test in the presence of APOE epsilon4 in community-dwelling elders diagnosed with MCI.

Keyword

Mild cognitive impairment; Apolipoprotein E; high-density lipoprotein cholesterol; Korean version of Consortium to Establish a Registry of Alzheimer's Disease; Cognitive function

MeSH Terms

Aged
Alzheimer Disease
Apolipoproteins
Apolipoproteins E
Cholesterol
Humans
Lipoproteins
Male
Memory, Episodic
Mild Cognitive Impairment
Neuropsychological Tests
Apolipoproteins
Apolipoproteins E
Cholesterol
Lipoproteins