Korean J Dermatol.  2007 Sep;45(9):969-972.

Treatment of Generalized Granuloma Annulare with Low-dose Hydroxychloroquine

• Kim CY
• Park SY
• Oh CW

Abstract

Generalized granuloma annulare (GGA) is benign granulomatous dermatosis of unknown causes characterized by a widespread papular eruption on the trunk and limbs. This differs from the localized form as it is distinguished by later onset, a protracted response to therapy, and concomitant diabetes mellitus in 20% of patients. GGA is a chronic disease with a relapsing course and a poor long term response to treatment, GGA lasted for 5 or more years in 25% of patients. Thus, more safe and effective therapeutic modalities are needed. The effectiveness and safety of hydroxychloroquine (6.5 mg/kg/day) which has a long history of efficacy in systemic lupus erythematosus is identified. We report a case of 48-year-old man presented with GGA lesions successfully treated with a low dose hydroxychloroquine (3 mg/kg/day) without side effect and the clinical improvement observed after 2 weeks. Low doses of hydroxychloroquine might be beneficial in the treatment of GGA, compared with other drugs, with low potency of side effect.

Keyword

Granuloma annulare; Generalized; Hydroxychloroquine; Low dose

MeSH Terms

Chronic Disease
Diabetes Mellitus
Extremities
Granuloma Annulare*
Granuloma*
Humans
Hydroxychloroquine*
Lupus Erythematosus, Systemic
Middle Aged
Skin Diseases
Hydroxychloroquine