Korean J Dermatol.
2018 Aug;56(7):437-442.
Three Cases of Generalized Granuloma Annulare Successfully Treated with Methotrexate
- Affiliations
-
- 1Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea. dockbs@pusan.ac.kr
- 2Department of Dermatology, Pusan National University Yangsan Hospital, Yangsan, Korea.
- 3Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
Abstract
- Granuloma annulare is a benign granulomatous skin disease, clinically characterized by dermal papules tending to form annular shapes. Granuloma annulare is classified into localized, generalized, subcutaneous, and perforating types. Localized granuloma annulare is likely to resolve spontaneously, while generalized granuloma annulare usually takes a chronic course. Topical steroids, phototherapy, isotretinoin, dapsone, hydroxychloroquine, and other various treatments have been proposed, but some cases have been resistant to all of those treatment modalities. We experienced 3 cases of generalized granuloma annulare demonstrating a recalcitrant course that were successfully treated with methotrexate and propose that methotrexate may be an effective option for recalcitrant generalized granuloma annulare treatment.
