Korean J Infect Dis.  1998 Jun;30(3):300-303.

A Case of Nocardiosis after Bone Marrow Transplantation

Affiliations
  • 1Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.

Abstract

The nocardiae are gram-positive, aerobic actinomycetes causing opportunistic infections in compromised hosts, such as recipients of solid organ transplants, patients with AIDS, and patients with cancer receiving immunosuppressive therapy, and those with chronic illnesses. Because cellular immunity and neutrophil function are critical for the clearance of Nocardia, frequent infection with the organism would be expected amongmarrow recipients, but reports of nocardiosis are surprisingly rare among these patients. We report a case of nocardiosis sixteen months after an allogenic bone marrow transplantation. The patient was successfully treated with imipenem and amikacin for 4 weeks and then with oral trimethoprim-sulfamethoxazole.

Keyword

Nocardiosis; Bone marrow transplantation

MeSH Terms

Actinobacteria
Amikacin
Bone Marrow Transplantation*
Bone Marrow*
Chronic Disease
Humans
Imipenem
Immunity, Cellular
Neutrophils
Nocardia
Nocardia Infections*
Opportunistic Infections
Transplants
Trimethoprim, Sulfamethoxazole Drug Combination
Amikacin
Imipenem
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