Korean J Dermatol.  2011 Nov;49(11):1017-1020.

CD 4+/CD56+ Hematodermic Neoplasm in Infancy: Case Report

• Suhng EA
• Cheong SH
• Choi HY
• Myung KB
• Choi YW

Abstract

CD4+/CD56+ hematodermic neoplasm is a rare and aggressive lesion that affects many organs, and skin involvement is highly characteristic. It is also termed blastic natural killer cell lymphoma in the World Health Organization classification. Several origins of tumor cells have been proposed, but recent studies have shown a relationship with plasmacytoid dendritic cells. A 2-year-old boy presented with multiple bruise-like violaceous subcutaneous nodules and plaques on the trunk, upper and lower extremities. Histological examination showed small-to-medium-sized blastoid cellular infiltration in the dermis and subcutaneous tissue. Tumor cells were positive for CD4, CD56 and TdT, and negative for CD8, CD20 and MPO. It primarily affects elderly patients, but, in this case, occurred in an infant. Due to its rarity, we present a case of CD4+/CD56+ hematodermic neoplasm affecting a pediatric patient.

Keyword

Blastic NK-cell lymphoma; CD4+/CD56+ hematodermic neoplasm

MeSH Terms

Aged
Dendritic Cells
Dermis
Humans
Infant
Killer Cells, Natural
Lower Extremity
Lymphoma
Preschool Child
Skin
Subcutaneous Tissue
World Health Organization