Korean J Health Promot.  2015 Sep;15(3):91-97. 10.15384/kjhp.2015.15.3.91.

The Relationship between Uric Acid and Homocysteine Levels based on Alcohol-related Facial Flushing

• Kim EC
• Kim JS
• Uh WC
• Choi SY
• Lee SK
• Jeong BS

• KMID: 2247202
• DOI: http://doi.org/10.15384/kjhp.2015.15.3.91

Abstract

BACKGROUND
This study aimed to determine the correlation between blood uric acid and homocysteine levels, based on alcohol-related facial flushing.
METHODS
Among male adults who visited a health examination center of a university hospital located in Daejeon, Korea, for a personal health examination from March 2013 to February 2014, 702 subjects were analyzed including 401 subjects without alcohol-related facial flushing and 301 with facial flushing. Pearson's correlation and stepwise multivariate linear regression analyses were performed between the log homocysteine levels and other variables including uric acid.
RESULTS
Uric acid showed a significant positive correlation with log homocysteine (gamma=0.166, P=0.001) (beta=0.176; P=0.001) in the non-flushing group. In contrast, none of the variables showed any significant correlations with log homocysteine in the flushing group.
CONCLUSIONS
Alcohol users not exhibiting alcohol-related facial flushing showed a positive correlation between uric acid and homocysteine levels, whereas those without facial flushing showed no such correlation.

Keyword

Homocysteine; Uric acid; Flushing; Alcohol drinking

MeSH Terms

Adult
Alcohol Drinking
Flushing*
Homocysteine*
Humans
Korea
Linear Models
Male
Uric Acid*
Homocysteine
Uric Acid

Reference

1.Iseki K., Ikemiya Y., Inoue T., Iseki C., Kinjo K., Takishita S. Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort. Am J Kidney Dis. 2004. 44(4):642–50.

2.Feig DI., Soletsky B., Johnson RJ. Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA. 2008. 300(8):924–32.

3.Strasak A., Ruttmann E., Brant L., Kelleher C., Klenk J., Concin H, et al. Serum uric acid and risk of cardiovascular mortality: a prospective long-term study of 83,683 Austrian men. Clin Chem. 2008. 54(2):273–84.

4.Nakagawa T., Hu H., Zharikov S., Tuttle KR., Short RA., Glushakova O, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol. 2006. 290(3):F625–31.

5.Khanna D., Fitzgerald JD., Khanna PP., Bae S., Singh MK., Neogi T, et al. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken). 2012. 64(10):1431–46.

6.Roddy E., Doherty M. Epidemiology of gout. Arthritis Res Ther. 2010. 12(6):223.

7.Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999. 19:217–46.

8.McCully KS. Homocysteine and vascular disease. Nat Med. 1996. 2(4):386–9.

9.Eikelboom JW., Lonn E., Genest J Jr., Hankey G., Yusuf S. Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence. Ann Intern Med. 1999. 131(5):363–75.

10.Refsum H., Ueland PM., Nygård O., Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998. 49(1):31–62.

11.Nygård O., Vollset SE., Refsum H., Brattström L., Ueland PM. Total homocysteine and cardiovascular disease. J Intern Med. 1999. 246(5):425–54.

12.Marti F., Vollenweider P., Marques-Vidal PM., Mooser V., Waeber G., Paccaud F, et al. Hyperhomocysteinemia is independently associated with albuminuria in the population-based CoLaus study. BMC Public Health. 2011. 11:733.

13.Malinow MR., Levenson J., Giral P., Nieto FJ., Razavian M., Segond P, et al. Role of blood pressure, uric acid, and hemorheo-logical parameters on plasma homocyst(e)ine concentration. Atherosclerosis. 1995. 114(2):175–83.

14.Tsutsumi Z., Moriwaki Y., Yamamoto T., Takahashi S., Hada T., Fukuchi M. Total plasma homocysteine is not increased in Japanese patients with gout. J Rheumatol. 2002. 29(8):1805–6.

15.Choi ST., Kim JS., Song JS. Elevated serum homocysteine levels were not correlated with serum uric acid levels, but with decreased renal function in gouty patients. J Korean Med Sci. 2014. 29(6):788–92.

16.Crabb DW., Matsumoto M., Chang D., You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc. 2004. 63(1):49–63.

17.Suh HS., Kim JS., Kim SS., Jung JG., Yoon SJ., Ahn JB. Influence of the Flushing Response in the Relationship between Alcohol Consumption and Cardiovascular Disease Risk. Korean J Fam Med. 2014. 35(6):295–302.

18.Jung JG., Kim JS., Kim YS., Oh MK., Yoon SJ. Hypertension associated with alcohol consumption based on the facial flushing reaction to drinking. Alcohol Clin Exp Res. 2014. 38(4):1020–5.

19.Keys A., Fidanza F., Karvonen MJ., Kimura N., Taylor HL. Indices of relative weight and obesity. J Chronic Dis. 1972. 25(6):329–43.

20.National Institute on Alcohol Abuse and Alcoholism. Alcohol screening and brief intervention for youth: A practitioner's guide. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism;2011. [Accessed February 28, 2015].http://pubs.niaaa.nih.gov/publications/Practitioner/YouthGuide/YouthGuide.pdf.

21.Yokoyama A., Muramatsu T., Ohmori T., Kumagai Y., Higuchi S., Ishii H. Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk. Cancer Epidemiol Biomarkers Prev. 1997. 6(12):1105–7.

22.Levey AS., Stevens LA., Schmid CH., Zhang YL., Castro AF 3rd., Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009. 150(9):604–12.

23.Kim EC., Kim JS., Jung JG., Kim SS., Yoon SJ., Ryu JS. Effect of alcohol consumption on risk of hyperhomocysteinemia based on alcohol-related facial flushing response. Korean J Fam Med. 2013. 34(4):250–7.

24.Emmerson B. Hyperlipidaemia in hyperuricaemia and gout. Ann Rheum Dis. 1998. 57(9):509–10.

25.Meigs JB., Jacques PF., Selhub J., Singer DE., Nathan DM., Rifai N, et al. Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care. 2001. 24(8):1403–10.

26.Papezikova I., Pekarova M., Lojek A., Kubala L. The effect of uric acid on homocysteine-induced endothelial dysfunction in bovine aortic endothelial cells. Neuro Endocrinol Lett. 2009. 30(Suppl 1):112–5.

27.Hayden MR., Tyagi SC. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and athe-roscleropathy: the pleiotropic effects of folate supplementation. Nutr J. 2004. 3:4.

28.Nieto FJ., Iribarren C., Gross MD., Comstock GW., Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis. 2000. 148(1):131–9.

29.Fang J., Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA. 2000. 283(18):2404–10.

30.Barak AJ., Beckenhauer HC., Tuma DJ. Methionine synthase. a possible prime site of the ethanolic lesion in liver. Alcohol. 2002. 26(2):65–7.

31.Brecher AS., Lehti MD. A hypothesis linking hypoglycemia, hyperuricemia, lactic acidemia, and reduced gluconeogenesis in al-coholics to inactivation of glucose-6-phosphatase activity by acetaldehyde. Alcohol. 1996. 13(6):553–7.