Korean J Health Promot.  2015 Dec;15(4):202-208. 10.15384/kjhp.2015.15.4.202.

Association between Insulin Resistance and Benign Prostatic Hyperplasia in Healthy Middle-aged Korean Men

• Son H
• Suh B
• Kim S
• Myong J
• Shon Y
• Kim H
• Jeong H

• KMID: 2247046
• DOI: http://doi.org/10.15384/kjhp.2015.15.4.202

Abstract

BACKGROUND
We examined the association between insulin resistance assessed by homeostatic model assessment-insulin resistance (HOMA-IR) and benign prostatic hyperplasia (BPH) in healthy middle-aged male subjects.
METHODS
A cross-sectional study included 1,727 male subjects, aged 40-59 year, free of medication history for BPH who received a transrectal ultrasonography and completed a structured questionnaire in 2011. Multiple logistic regression analysis was performed to evaluate the relationships of HOMA-IR with BPH across the tertile of HOMA-IR.
RESULTS
The prevalence of BPH was 24.4% (421 out of 1,727). It was increased across HOMA-IR tertiles in crude and age-adjusted models. In a multivariable-adjusted model after adjusting potential confounders such as age, body mass index (BMI), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alcohol consumption, smoking, exercise and meat consumption, odds ratios (95% confidence intervals, CIs) of BPH for 2nd tertile and 3rd tertile compared to 1st tertile were 1.76 (1.31-2.35), and 1.83 (1.34-2.48), respectively.
CONCLUSIONS
In middle-aged, healthy men, higher HOMA-IR was significantly associated with higher prevalence of BPH, supporting insulin resistance as an independent risk factor for BPH.

Keyword

Insulin resistance; Benign prostatic hyperplasia; Middle-aged

MeSH Terms

Alcohol Drinking
Body Mass Index
Cholesterol, HDL
Cholesterol, LDL
Cross-Sectional Studies
Humans
Insulin Resistance*
Insulin*
Logistic Models
Male
Meat
Odds Ratio
Prevalence
Prostatic Hyperplasia*
Risk Factors
Smoke
Smoking
Triglycerides
Ultrasonography
Cholesterol, HDL
Cholesterol, LDL
Insulin
Smoke

Figure

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  Figure 1. Flow for the selection of study subjects.

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