Korean J Dermatol.  2014 Feb;52(2):115-119.

A Case of Extensive Cutaneous Metastasis from Squamous Cell Carcinoma of the Uterine Cervix

• Jin H
• Kim WJ
• Mun JH
• Song M
• Kim HS
• Ko HC
• Kim MB
• Kim BS

Abstract

Carcinoma of the uterine cervix is a common malignancy for women in Korea. It frequently metastasizes to the lungs, bone, or liver, but cutaneous metastasis is rare, with a reported incidence of only 1.3%. In cases of cutaneous metastasis, the lesions present in the forms of nodules, ulcers, or plaques, and are generally located in the abdominal wall, vulva, anterior chest wall, lower extremities, and upper extremities. Here, we describe a case of a 64-year-old woman diagnosed with cutaneous metastases from squamous cell carcinoma of the uterine cervix on both flanks, lower abdominal wall, and both inguinal areas, three years after receiving chemoradiation therapy. At presentation, the primary carcinoma had been resolved completely. Histological and immunohistochemical findings revealed intact epidermis and infiltration of tumor cells in the dermis, which showed positivity for cytokeratin 5/6, cytokeratin 7, and tumor protein 63, consistent with metastatic squamous cell carcinoma of the uterine cervix.

Keyword

Cutaneous metastasis; Squamous cell carcinoma; Uterine cervical cancer

MeSH Terms

Abdominal Wall
Carcinoma, Squamous Cell*
Cervix Uteri*
Dermis
Epidermis
Female
Humans
Incidence
Keratin-7
Keratins
Korea
Liver
Lower Extremity
Lung
Middle Aged
Neoplasm Metastasis*
Thoracic Wall
Ulcer
Upper Extremity
Uterine Cervical Neoplasms
Vulva
Keratin-7
Keratins