Korean J Gynecol Oncol Colposc.
2004 Mar;15(1):29-34.
Increased Expression of GADD34 in Ovarian Carcinomas
- Affiliations
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- 1Department of Obstetrics and Gynecology, School of Medicine, Keimyung University, Daegu, Korea.
- 2Department of Physiology, School of Medicine, Keimyung University, Daegu, Korea.
Abstract
OBJECTIVE
: GADD34 was originally described as a growth arrest and DNA damage-inducible gene. Increased expression of GADD34 was subsequently found to correalate with apoptosis, and forced overexpression of the protein leads to apoptosis. In this study we evaluated the expression of GADD34 in ovarian cancers and normal ovarian tissues.
METHODS
: Fresh tissues were retrieved from 15 cases with ovarian cancers, 7 normal and 3 benign ovarian tissues. The expression of GADD34 in ovarian cancers compared with normal tissues were examined by RT-PCR, Western-blot analysis and immuno-histochemical analysis.
RESULTS
: The overexpression of GADD34 mRNA levels was identified in ovarian cancers compared with normal ovaries by RT-PCR assay. Using Western-blot analysis, the overexpression of GADD34 was observed in ovarian cancer tissues compared with normal ovarian tissues. On histochemical results, the expression of GADD34 were observed in ovarian cancer tissues.
CONCLUSION
: Increased expression of GADD34 in the ovarian carcinoma compared to normal ovarian tissues may play a part of role in pathogenesis of ovarian cancer.
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