Korean J Anesthesiol.
2008 Feb;54(2):225-228. 10.4097/kjae.2008.54.2.225.
Negative-pressure Pulmonary Edema by Doxapram-induced Larygospasm: A case report
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- 1Department of Anesthesiology and Pain Medicine, School of Medicine, Hanyang University, Seoul, Korea. yeomjh@hanyang.ac.kr
- KMID: 2244030
- DOI: http://doi.org/10.4097/kjae.2008.54.2.225
Abstract
- Doxapram is a peripheral and central respiratory stimulant, producing an increase in tidal volume and a slight increase in respiratory rate. It can temporarily overcome drug-induced respiratory and central nervous system depression, including that seen immediately postoperatively. However, it can also cause side effects, including laryngospasm and vomiting postoperatively. Doxapram-induced laryngospasm causes the increased respiratory efforts to induce more negative pleural pressure, thus causing a negative-pressure pulmonary edema.Therefore, doxapram should not be used if signs of upper airway obstruction are present.
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