Korean J Gastrointest Endosc.  2010 Jul;41(1):10-15.

A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy

• Kim EO
• Lee SH
• Kim DS
• Lee CK
• Lee TH
• Chung IK
• Park SH
• Kim SJ

Abstract

BACKGROUND/AIMS
We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy.
METHODS
A total of 133 patients undergoing colonoscopy were randomized to receive either 20 mg of hyoscine-N-butyl bromide (n=70) or normal saline solution (n=63) via intramuscular injection as premedication.
RESULTS
The mean cecal intubation time and withdrawal time in the hyoscine-N-butyl bromide group were significantly shorter than those of the control group (5.26+/-2.78 min vs. 6.74+/-4.89 min; p=0.032, 5.42+/-1.54 min vs. 6.18+/-2.54 min; p=0.038, each). The spasm grade in the hyoscine-N-butyl bromide group was significantly lower than that of the control group (p<0.001). No significant differences were found in the polyp detection rate (15.7% vs. 28.6%; p=0.073) and adenoma detection rate (10.0% vs. 15.9%; p=0.311). Difficulty of colonoscopy for the endoscopists and nurses (p=0.853; p=0.732), the patient's comfort (p=0.891) and the patient's willingness to repeat colonoscopy (85.7% vs. 82.5%; p=0.932) were also similar in both groups.
CONCLUSIONS
Premedication with intramuscularly administered hyoscine-N-butyl bromide do not demonstrate any additional benefits except reducing the colonoscopy insertion time.

Keyword

Colonoscopy; Premedication; Antispasmodics; Hyoscine-N-butyl bromide

MeSH Terms

Adenoma
Colonoscopy
Humans
Injections, Intramuscular
Intubation
Parasympatholytics
Polyps
Premedication
Prospective Studies
Scopolamine Hydrobromide
Sodium Chloride
Spasm
Parasympatholytics
Scopolamine Hydrobromide
Sodium Chloride