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Successful Treatment of Neonatal Pylorospasm with Intravenous Atropine

Kim HJ, Shin JE, Han JH, Lim JH, Lee SM, Park MS, Park KI, Namgung R, Eun HS

Pylorospasm is a cause of delayed gastric emptying in young infants. As in patients with hypertrophic pyloric stenosis, most pylorospasm patients present with projectile vomiting. However, unlike that in case...
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Ultrasound-Guided Botulinum Toxin Injection with Factor VIII Administration for Post Stroke Spasticity in a Hemophilia A Patient

Shin MA, Lee SH, Lee JM, Shin JH

Chemodenervation with botulinum toxin (BTX) has been recommended for focal spasticity. BTX injection should be performed with caution in patients with bleeding disorders and/or receiving anticoagulation therapy. We present a...
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Effect of antispasmodic agents for the treatment of irritable bowel syndrome

Lee SH, Jee SR

Antispasmodics are effective in reducing abdominal pain and controlling spasm. Irritable bowel syndrome (IBS) patients have characteristic key factors such as intestinal motility disorder and visceral hypersensitivity. So antispasmodics have...
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Methidathion Poisoning

Kim KH, Kim SH, Her C

Although methidathion is an organophosphate insecticide, it is different from the other organophosphates in terms of toxicity. Because of its relatively high fat solubility, the apparent volume of methidathion distribution...
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Pharmacotherapy of irritable bowel syndrome

Park CH, Han DS

Irritable bowel syndrome is a group of symptoms that includes abdominal pain and changes in the form and frequency of stool. Since its symptoms are usually long-lasting, the disease significantly...
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Pharmacologic Agents for Chronic Diarrhea

Lee KJ

Chronic diarrhea is usually associated with a number of non-infectious causes. When definitive treatment is unavailable, symptomatic drug therapy is indicated. Pharmacologic agents for chronic diarrhea include loperamide, 5-hydroxytryptamine type...
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Comparison between the Effectiveness of Oral Phloroglucin and Cimetropium Bromide as Premedication for Diagnostic Esophagogastroduodenoscopy: An Open-Label, Randomized, Comparative Study

Yun HW, Shim KN, Na SK, Ryu JI, Lee MJ, Song EM, Kim SE, Jung HK, Jung SA

BACKGROUND/AIMS: Suppression of gastrointestinal (GI) peristalsis during GI endoscopy commonly requires antispasmodic agents such as hyoscine butylbromide, atropine, glucagon, and cimetropium bromide. This study examined the efficacy of oral phloroglucin...
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Strategy to Manage Irritable Bowel Syndrome in Korea

Kim JH, Sung IK

  • KMID: 2269332
  • Korean J Med.
  • 2014 Jun;86(6):695-697.
Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal disorders. It is a multi-factorial disorder due to abnormal gastrointestinal motility, low-grade inflammation, visceral hypersensitivity, and communication between...
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Efficacy and Safety of Tiropramide in the Treatment of Patients With Irritable Bowel Syndrome: A Multicenter, Randomized, Double-blind, Non-inferiority Trial, Compared With Octylonium

Lee KN, Lee OY, Choi MG, Sohn CI, Huh KC, Park KS, Kwon JG, Kim N, Rhee PL, Myung SJ, Lee JS, Lee KJ, Park H, Lee YC, Choi SC, Jung HK, Jee SR, Choi CH, Kim GH, Park MI, Sung IK

  • KMID: 2381156
  • J Neurogastroenterol Motil.
  • 2014 Jan;20(1):113-121.
BACKGROUND/AIMS: Antispasmodics such as octylonium are widely used to manage irritable bowel syndrome (IBS) symptoms. However, the efficacy and safety of another antispasmodic, tiropramide, remain uncertain. We aimed to evaluate...
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The Usefulness of the Hot Pack as a Complementary Technique for the Treatment of Non-specific Abdominal Pain or Acute Gastroenteritis in an Emergency Department

Moon JH, Cho GC, Cho CH, Ryu JY, Ahn JH

  • KMID: 2333567
  • J Korean Soc Emerg Med.
  • 2013 Dec;24(6):702-708.
PURPOSE: The aim of this study was to determine the effectiveness of the hot pack as a complementary technique for the treatment of nonspecific abdominal pain or acute gastroenteritis in...
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Efficacy of Fenoverine and Trimebutine in the Management of Irritable Bowel Syndrome: Multicenter Randomized Double-blind Non-inferiority Clinical Study

Kang SH, Jeen YT, Koo JS, Koo YS, Kim KO, Kim YS, Kim SY, Moon JS, Park JJ, Baek IH, Park SC, Lee SJ, Lee JH, Choung RS, Choi SC

BACKGROUND/AIMS: Antispasmodic agents have been used in the management of irritable bowel syndrome. However, systematic reviews have come to different conclusions about the efficacy in irritable bowel syndrome. Fenoverine acts...
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Irritable Bowel Syndrome and Migraine: Bystanders or Partners?

Chang FY, Lu CL

  • KMID: 2326229
  • J Neurogastroenterol Motil.
  • 2013 Jul;19(3):301-311.
Irritable bowel syndrome (IBS) and migraine are distinct clinical disorders. Apart from the characteristics of chronic and recurrent pain in nature, these pain-related disorders apparently share many similarities. For example,...
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Anaphylaxis caused by muscle relaxant (eperisone hydrochloride)

Kim SH, Lee J, Kim SH, Kim HW, Kim YU, Lim Y, Moon S, Moon J, Heo D

Eperisone hydrochloride is an antispasmodic drug, decreasing spasticity of skeletal muscle and alleviating stiffness, and as a consequence, controlling pain. It is preferably prescribed with other analgesics, beneficially less decreasing...
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The Evaluation of Otilonium Bromide Treatment in Asian Patients With Irritable Bowel Syndrome

Chang FY, Lu CL, Luo JC, Chen TS, Chen MJ, Chang HJ

  • KMID: 2325842
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):402-410.
BACKGROUND/AIMS: Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to...
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Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome

Chey WD, Maneerattaporn M, Saad R

  • KMID: 2284205
  • Gut Liver.
  • 2011 Sep;5(3):253-266.
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by episodic abdominal pain or discomfort in association with altered bowel habits (diarrhea and/or constipation). Other gastrointestinal symptoms, such...
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Treatment of Irritable Bowel Syndrome

Lee KJ

  • KMID: 2258946
  • Korean J Med.
  • 2011 May;80(5):499-504.
Irritable bowel syndrome (IBS) is a common gastrointestinal condition and its pathophysiology remains to be unestablished. Traditional symptom-based therapies of IBS are directed at the relief of individual IBS symptoms....
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Guidelines for the Treatment of Irritable Bowel Syndrome

Kwon JG, Park KS, Park JH, Park JM, Park CH, Lee KJ, Park HJ, Rhee JC, The Korean Society of Neurogastroenterology and Motility

Traditional symptom-based therapies of irritable bowel syndrome (IBS) are directed at the relief of individual IBS symptoms, but they are often of limited efficacy in addressing the entire symptom complex....
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A Clinical Usefulness of Premedication with Hyoscine N-butyl Bromide in Colonoscopy

Kim EO, Lee SH, Kim DS, Lee CK, Lee TH, Chung IK, Park SH, Kim SJ

  • KMID: 2243103
  • Korean J Gastrointest Endosc.
  • 2010 Jul;41(1):10-15.
BACKGROUND/AIMS: We conducted a prospective, randomized, double-blinded, placebo-controlled trial to investigate the effect of hyoscine-N-butyl bromide during colonoscopy. METHODS: A total of 133 patients undergoing colonoscopy were randomized to receive either...
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A case report of alverine-citrate-induced acute hepatitis

Han JY, Lee JW, Kim JM, Joo K, Chon U, Lee JI, Jeong S, Lee DH, Kim YS, Min KS

Alverine citrate is one of the most commonly used antispasmodic drugs for patients with irritable bowel syndrome. Alverine-citrate-induced hepatotoxicity is extremely rare, with only a few cases having been reported...
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The Effect of Peppermint Oil on Peristalsis during Gastroscopy

Park S, Chun HJ, Kim ES, Park SC, Jung ES, Keum B, Seo YS, Jeen YT, Um SH, Kim CD, Ryu HS

  • KMID: 1466955
  • Korean J Gastrointest Endosc.
  • 2009 Oct;39(4):199-204.
BACKGROUND/AIMS: Gastrointestinal peristalsis may hinder inspection of the gastrointestinal track or its treatment during endoscopy. Antispasmodic agents such as hyoscine-N-butylbromide are commonly administered before endoscopy for alleviating peristalsis, although it...
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