Korean J Anesthesiol.  2008 Nov;55(5):543-548. 10.4097/kjae.2008.55.5.543.

The comparison of intravenous anesthesia with fentanyl versus alfentanill during oocyte retrieval for in vitro fertilization

• Kang YI
• Bang EC
• Lee HS
• Cho KS
• Kim SY
• Sul JH
• Kim JY
• Yoon TG
• Seok HH

• KMID: 2242991
• DOI: http://doi.org/10.4097/kjae.2008.55.5.543

Abstract

BACKGROUND
This study was carried out to compare the effect of intravenous anesthesia with fentanyl or alfentanil on the hemodynamic profile, sedation, recovery and side effect in the patients undergoing oocyte retrieval.
METHODS
The patients were designed to receive alfentanil (group A, n = 70) or fentanyl (group F, n = 70) intravenous anesthesia. The patients were given midazolam 0.6 mg/kg and alfentanil 15 microgram/kg in group A or fentanyl 1.5 microgram/kg in group F. Propofol 0.7 mg/kg was given if patient was awaken during procedure. Hemodynamic changes, propofol used dosage and initial propofol injecting time, Ramsay Sedation Scales, cough reflex on opioid injection, recovery time, duration of apnea and postoperative nausea, vomiting at the recovery room were recorded.
RESULTS
Group A had rapid onset, deep sedation, less amount of propofol used, more frequent apnea than group F. There were no significant differences in postoperative nausea, vomiting and recovery time between the two groups.
CONCLUSIONS
The intravenous anesthesia with fentanyl or alfentanil are suitable for oocyte retreival but apnea happened more frequent in alfentanil group, so the use of alfentanil needs to monitor ventilation and hemodynamic changes carefully.

Keyword

alfentanil; fentanyl; oocyte retrieval

MeSH Terms

Alfentanil
Anesthesia, Intravenous
Apnea
Cough
Deep Sedation
Fentanyl
Fertilization in Vitro
Hemodynamics
Humans
Midazolam
Oocyte Retrieval
Oocytes
Organothiophosphorus Compounds
Postoperative Nausea and Vomiting
Propofol
Recovery Room
Reflex
Ventilation
Vomiting
Weights and Measures
Alfentanil
Fentanyl
Midazolam
Organothiophosphorus Compounds
Propofol