J Bone Metab.
2014 May;21(2):155-159. 10.11005/jbm.2014.21.2.155.
Atypical Femoral Fracture Combined with Osteonecrosis of Jaw During Osteoporosis Treatment with Bisphosphonate
- Affiliations
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- 1Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea.
- 2Department of Orthopaedic Surgery, Yonsei Univeristy College of Medicine, Seoul, Korea. kyang@yuhs.ac
- 3Department of Orthopaedic Surgery, Aju University College of Medicine, Suwon, Korea.
- KMID: 2241537
- DOI: http://doi.org/10.11005/jbm.2014.21.2.155
Abstract
- Bisphosphonate, a potent anti-resorptive agent, is generally accepted as a safe, effective, well tolerated treatment for postmenopausal osteoporosis. Atypical femoral fracture (AFF) and bisphosphonate related osteonecrosis of jaw (BRONJ) are the increasing morbidities in patients treated with long term bisphosphonate. Pathogenic mechanisms of AFF and BRONJ are not fully identified and not identical. We report a case of BRONJ followed by AFF and its nonunion in a 67-year-old woman patient receiving an oral bisphosphonate during 7 years for the treatment of osteoporosis.
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