Korean J Gastroenterol.
1997 Sep;30(3):415-419.
Confirmation of Tuberculous Hepatitis Using Polymerase Chain Reaction
Abstract
- A 29-year-old patient developed an adverse reaction to antituberculous drugs adrninistered for tuberculous pleurisy. In spite of discontinuation of anti-tuberculous medication for 6 months, alkaline phsophatase level continuously increased and serum transaminase levels remained still high. Liver needle biopsy revealed multiple small collections of clear cells as well as nonspecific hepatitis and failed to demonstrate epithelioid granuloma or acid-fast bacilli by Ziehl-Neelsen staining. However, using the polymerase chain reaction technique, we confirmed hepatic invovement of tuberculosis based on the result of amplified Mycobacteriurn-specific DNA fragment.
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