Korean J Gastroenterol.
1999 May;33(5):615-623.
Helicobacter pylori and Expression of p53 Protein in Gastric Cancer
Abstract
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BACKGROUND/AIMS: Epithelial cell proliferation during Helicobacter pylori (H. pylori) infection is likely to promote neoplastic transformation in combination with additional factors such as genetic alterations and oncoprotein overexpression. Mutation of p53 might be occurred from overexpression of it. The aim of this study was to demonstrate the relationship between expression of p53 protein and H. pylori associated gastric cancer.
METHODS
H. pylori infection was studied in fifty-four cases of gastric adenocarcinoma. Among them, 38 cases were surgically resected and remaining cases were endoscopically resected. All of them were examined by immunohistological stain for detection of p53 protein.
RESULTS
H. pylori positivity was 46.3% of 54 cases with gastric adenocarcinoma. In 26 case of early gastric cancer, it was 69.2% and it was 21.4% in advanced gastric cancer. The p53 protein was detected in 86.8% of the patients who underwent gastric cancer resection, 94.1% of the patients with H. pylori positive cancer and 81.0% of the patients with H. pylori negative cancer. The p53 expression rate was high in the patients with H. pylori positive cancer, but statistically not signifi cant. In addition, expression of p53 protein was not related with Lauren' s type of gastric cancer
CONCLUSIONS
High prevalence of H. pylori infection was observed in early gastric cancer and expres sion of p53 protein was not related with H. pylori positive cancer.
