Korean J Anesthesiol.  1998 Nov;35(5):852-860. 10.4097/kjae.1998.35.5.852.

Hemodynamic Responses to Dobutamine, Hydralazine and Sodium Nitroprusside Following Pentastarch Infusion during Cardiac Tamponade in Dogs

• Kim JM
• Lee JH
• Jang YH
• Cheun JK

• KMID: 2240094
• DOI: http://doi.org/10.4097/kjae.1998.35.5.852

Abstract

Background: Cardiac tamponade results in a hemodynamic disorder associated with decreased cardiac output and blood pressure. To improve cardiac output in a subject with cardiac tamponade, cardiotonic drugs and vasodilators with blood volume expander can be used. The purpose of this study was to observe the hemodynamic effects of cardiotonic drugs and vasodilators following administration of plasma expander in the dogs with cardiac tamponade. Method: Three groups of dogs were studied during the induced cardiac tamponade. Following infusion of pentastarch, group I received dobutamine by dripping of 10 microg/kg/min, followed by injection of 20 microg/kg/min, group II received hydralazine (20 mg, 40 mg) and group III received sodium nitroprusside (5 microg/kg/min, 10 microg/kg/min). The heart rate, blood pressure, cardiac output and pulmonary arterial occluded pressure were measured. The atrial transmural pressure was calculated by subtracting intrapericardial pressure from mean atrial pressure.
Results
Cardiac output was increased in the groups I and II, but mean arterial pressure was increased in only the group I. Atrial transmural pressure was not changed in all three groups.
Conclusion
The most pronounced hemodynamic improvements during the cardiac tamponade is observed in group I with pentastarch-dobutamine combination.

Keyword

Heart: tamponade; cardica output; Phamacology: dobutamine; hydralazine; nitroprusside

MeSH Terms

Animals
Arterial Pressure
Atrial Pressure
Blood Pressure
Blood Volume
Cardiac Output
Cardiac Tamponade*
Cardiotonic Agents
Dobutamine*
Dogs*
Heart Rate
Hemodynamics*
Hydralazine*
Hydroxyethyl Starch Derivatives*
Nitroprusside*
Plasma
Vasodilator Agents
Cardiotonic Agents
Dobutamine
Hydralazine
Hydroxyethyl Starch Derivatives
Nitroprusside
Vasodilator Agents