Korean J Anesthesiol.  2001 Oct;41(4):473-483. 10.4097/kjae.2001.41.4.473.

Comparison of Amrinone and Dopamine-Nitroglycerin on Hemodynamic Parameters in Dogs with Postinfarct Heart Failure

• Kim SJ
• Oh JH
• Park JW
• Jung YH
• Oh HJ
• Oh SW
• Woo YC
• Kim JY
• Koo GH
• Park SG

• KMID: 2240016
• DOI: http://doi.org/10.4097/kjae.2001.41.4.473

Abstract

BACKGROUND
Left ventricular failure (LVF) after an acute myocardial infarction occurs during the perioperative period, and since this condition can lead to severe complications, intensive care is required for the patient. LVF is characterized hemodynamically by a raised left heart filling pressure and volume and global depression of the hearts pumping performance. Several effective drugs for patients with heart failure are catecholamines such as dopamine and dobutamine, vasodilators such as nitroglycerin and nitroprusside, and noncatecholamine inotropes such as amrinone, which are either infused alone or in combination. However, as of now, there has been no study as to clarifying either the exact dosage, drug combination, or how they affect the heart.
METHODS
By inducing a state of experimental acute left ventricular failure in 20 dogs through ligation of the left anterior descending coronary artery, this study compared the hemodynamic parameters of two treatment groups-one group using amrinone alone (bolus 1 mg/kg, continuous infusion 15micro gram/kg/min), and another group using a combination of dopamine (10micro gram/kg/min) and nitroglycerin (2micro gram/kg/min).
RESULTS
Cardiac output of dogs with postinfarct heart failure increased in both treatment groups. But, there was a significant decrease in systemic vascular resistance, pulmonary vascular resistance and left ventricular end diastolic pressure in the group treated with amrinone than dopamine-nitroglycerin. Amrinone also revealed a favorable effect on oxygen utility.
CONCLUSIONS
These results showed that amrinone might be more effective than the combination of dopamine and nitroglycerin for acute left ventricular failure in terms of myocardial function, hemodynamic stability and oxygen utility.

Keyword

hemodynamics; ventricular function; amrinone; dopamine; nitroglycerin

MeSH Terms

Amrinone*
Animals
Blood Pressure
Cardiac Output
Catecholamines
Coronary Vessels
Depression
Dobutamine
Dogs*
Dopamine
Heart Failure*
Heart*
Hemodynamics*
Humans
Critical Care
Ligation
Myocardial Infarction
Nitroglycerin
Nitroprusside
Oxygen
Perioperative Period
Vascular Resistance
Vasodilator Agents
Ventricular Function
Amrinone
Catecholamines
Dobutamine
Dopamine
Nitroglycerin
Nitroprusside
Oxygen
Vasodilator Agents