Korean J Anesthesiol.  2009 Dec;57(6):693-697. 10.4097/kjae.2009.57.6.693.

The effects of lidocaine and fentanyl on airway irritability during inhalation induction with desflurane

• Choi IG
• Choi YS
• Min JH
• Kim YH
• Chae YK
• Lee WK
• Lee YK
• Lee AR
• Cho HR
• Chae HS

• KMID: 2239784
• DOI: http://doi.org/10.4097/kjae.2009.57.6.693

Abstract

BACKGROUND
Inhalation induction with desflurane can cause airway irritability and sympathetic stimulation. The aim of this study was to investigate whether lidocaine and fentanyl could reduce these unwanted reactions. METHODS: Seventy-five patients who had premedication with midazolam were randomly allocated to one of three groups to receive intravenous saline (S group), lidocaine 1.5 mg/kg (L group), fentanyl 1 microgram/kg (F group), respectively, before tidal volume induction with desflurane in oxygen and nitrous oxide. We recorded airway irritability such as cough, apnea, laryngospasm and excitatory movement and hemodynamic changes. RESULTS: Airway irritability was not significantly different between the groups. In F group, mean blood pressure at LOC ver and LOC BIS and heart rate at LOC ver, LOC BIS and just before intubation were lower than those of S group (P < 0.05). Other results were not significantly different. CONCLUSIONS: The results of the study showed that intravenous fentanyl and lidocaine had no beneficial effects to reduce airway irritability, but intravenous fentanyl could significantly reduce hemodynamic stimulation during inhalation induction with desflurane in the patients who were premedicated with midazolam.

Keyword

Airway irritability; Desflurane; Fentanyl; Lidocaine; Midazolam

MeSH Terms

Apnea
Blood Pressure
Cough
Fentanyl
Heart Rate
Hemodynamics
Humans
Inhalation
Intubation
Isoflurane
Laryngismus
Lidocaine
Midazolam
Nitrous Oxide
Oxygen
Premedication
Tidal Volume
Fentanyl
Isoflurane
Lidocaine
Midazolam
Nitrous Oxide
Oxygen