Korean J Anesthesiol.  2010 Nov;59(5):335-339. 10.4097/kjae.2010.59.5.335.

Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone

• Jee YS
• Yoon HJ
• Jang CH

• KMID: 2239763
• DOI: http://doi.org/10.4097/kjae.2010.59.5.335

Abstract

BACKGROUND
This study was conducted to compare the efficacy of a combination of ondansetron and dexamethasone with that of metoclopramide and dexamethasone for prevention of postoperative nausea and vomiting (PONV) in gynecologic patients receiving fentanyl IV-patient controlled analgesia.
METHODS
One hundred patients were divided into two groups at random. In Group O, 5 mg of dexamethsone was administered after tracheal intubation, while 4 mg of ondansetron was administered at the end of surgery. In Group M, 5 mg of dexamethsone was administered after tracheal intubation and 20 mg metoclopromide was administered at the end of surgery. During the experiment, the PONV was evaluated at regular intervals. In addition, the incidence of nausea, and vomiting and the numerical rating scale (NRS) of nausea was measured (range, 0-10).
RESULTS
The overall incidence of PONV in Group O was 22/50 (44%) while that in Group M was 19/50 (38%). There were no significant differences in the incidence of nausea, moderate to severe nausea (NRS of nausea, 4-10), or vomiting between groups.
CONCLUSIONS
Treatment with a combination of 20 mg metoclopramide and 5 mg dexamethasone is an effective, safe, and inexpensive way to prevent PONV when compared to treatment with 4 mg ondansetron and 5 mg dexamethasone.

Keyword

Dexamethasone; Metoclopramide; Ondansetron; Postoperative nausea and vomiting

MeSH Terms

Analgesia
Antiemetics
Dexamethasone
Fentanyl
Humans
Incidence
Intubation
Metoclopramide
Nausea
Ondansetron
Postoperative Nausea and Vomiting
Vomiting
Antiemetics
Dexamethasone
Fentanyl
Metoclopramide
Ondansetron