Korean J Anesthesiol.  1987 Aug;20(4):462-469. 10.4097/kjae.1987.20.4.462.

The Effect of Vecuronium on the Intraocular Pressure

• Han SY
• Lee MK
• Chae BK
• Shin JS

• KMID: 2239514
• DOI: http://doi.org/10.4097/kjae.1987.20.4.462

Abstract

In ocular surgery, many studies have been carried but in order to evaluate intraocular pressure chance during induction and maintenance of anesthesia. In this study, Vecuronium (Norcuron), new monoquaternary analogue of pancuronium, has been used in a group of patient undergoing elective sugery in order to evaluate its influe-nce on intraocular pressure. 40 patients without a history of eye digease, in age from 20 to 60 years, were evaluated. Their condition fell into ASA class l. On arrival, initial measurement of intraocular pressure(as control value) was taken with Shiotg tonometer after instilling a 0.5% pontocaine into conjuntival sac. Subsequent measurements were taken after thiopental injeotion as soon at the lid reflex was lost, then 2 minutes after Vecuronium injection, 1,3,5,10 and 20 minutes after endot-racheal intuhation. Blood pressure and pulse rate were measured together. The results were as follows, 1. At 2 minutes after intubation, intraocular pleasure was decreased as compared with the control value. 2. At 1 minute after intutation, intraocular pressure was more increased than the value of 2 minutes after vecuronium injection. but was not significantly changed as compared with control valule. 3. All values measured followed 3 minutes after intubation were significantly derceased. 4. Mean arterial pressure and pulse rate were increased at 1 minute after intubation but all the other values were not significantly changed as compared with control value.

MeSH Terms

Anesthesia
Arterial Pressure
Blood Pressure
Heart Rate
Humans
Intraocular Pressure*
Intubation
Pancuronium
Pleasure
Reflex
Tetracaine
Thiopental
Vecuronium Bromide*
Pancuronium
Tetracaine
Thiopental
Vecuronium Bromide