Korean J Anesthesiol.  1988 Feb;21(1):39-43. 10.4097/kjae.1988.21.1.39.

Inhibition of the Cardiovascular Response to Tracheal Intubation by Low - dose Fentanyl

• Chung CK

• KMID: 2239482
• DOI: http://doi.org/10.4097/kjae.1988.21.1.39

Abstract

The hemodynamic response evoked by tracheal intubation was observed in 20 adult normotensive patients undergoing elective surgery. Patients were randomly assigned to receive either thiopental 6 mg/kg(n=10) or fentanyl 6ug/kg with thiopental 3mg/kg(n=10), for induction of anesthesia. Systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP) and heart rate(HR) were measured at 1 min., 3 min. and 5 min. after intubation. In the thiopental group, intubation caused a significant rise in SBP, DBP, MAP, HR(p<0.05) but each parameter returned to normal within 5 min. In the fentanyl thiopental group intubation caused little cardiovascular change, but within 5 minutes MAP decreased significantly from 101 mmHg to 83 mmHg(p<0.05). It is concluded that a low-dose of fentanyl which may cause minimal postoperative respiratory depression, significantly prevents postintubation hypertension when used as an adjunct to thiopental for the induction of anesthesia.

Keyword

Intubation-tracheal; Analgesics-fentanyl

MeSH Terms

Adult
Anesthesia
Fentanyl*
Heart
Hemodynamics
Humans
Hypertension
Intubation*
Respiratory Insufficiency
Thiopental
Fentanyl
Thiopental