Korean J Anesthesiol.  1988 Feb;21(1):1-10. 10.4097/kjae.1988.21.1.1.

Effects of Verapamil on the Hemodynamic Responses to Nitroglycerin during Halothane-N2O Anesthesia

• Nah SS
• Park CJ
• Chung SS

• KMID: 2239477
• DOI: http://doi.org/10.4097/kjae.1988.21.1.1

Abstract

Hemodynamic variables in 8 verapamil pretreated patients(the verapamil pretreated group) were compared with those in 10 patients without pretreatment(the control group) during nitroglycerin(NTG) induced hypotension under halothane-N2O anesthesis. The results were as follows: 1) In the control group, there were statistically significant decreases in mean arterial pressure (MAP)(25%), pulmonary arterial pressure(PAP)(32%), pulmonary capillary wedge pressure(PCWP)(30%), central venous pressure(CVP)(33%), but the heart rate(HR), cardiac output(CO), cardiac index(CI) and stroke volume index(SVI) remained unchanged. After discontinuance of NTG, all parameters returned to baseline levels. 2) Verapamil alone produced a small decrease in MAP(6%) and CVP(9%), but other hemodynamic values did not change. 3) In the verapamil pretreated group, there were significant decreases in MAP(23%), PAP(30%), PCWP(27%), CVP(20%), SVR(24%) and PVR(31%), but HR, CO, CI, and SVI remained unchanged. 4) These results indicated that verapamil did not significantly affect the hemodynamic response to NTG under halothane-N2O Anesthesis.

Keyword

Verapamil; Nitroglycerime; Hemodynamic responses

MeSH Terms

Anesthesia*
Arterial Pressure
Capillaries
Heart
Hemodynamics*
Humans
Hypotension
Nitroglycerin*
Stroke Volume
Verapamil*
Nitroglycerin
Verapamil