Korean J Anesthesiol.  1993 Apr;26(2):243-249. 10.4097/kjae.1993.26.2.243.

Dose - response for Glycopyrrloate and Heart Rate in Children Anesthetized with Halothane and Nitrous Oxide

• Son JY
• Kang PS
• Park YC
• Yoon SM

• KMID: 2239250
• DOI: http://doi.org/10.4097/kjae.1993.26.2.243

Abstract

The dose-response for glycopyrrolate and heart rate in anesthetized children has not heen defined. We determined the dose-response for glyeopyrrolate and heart rate in 50 children, ASA physical status l and 2, anesthetized with halothane and nitrous oxide. Anesthesia was induced with 60-70% nitrous oxide in oxygen and halothane(1.5-2.0 vo1%). After induction of aneethesia, glycopyrrolate in a dose of 4, 6, 8, 12 or 16ug Xkg(-1) was administered by rapid infusion to each subject. The effects of glycopyrrolate on heart rate, heart rhythm and systolic blood pressure were compared among dosage groups, and dose-response curve for peak heart rate was constructed, Glycopyrrolate increased the heart rate in a dose-related manner upto 12 ug X kg(-1) except 16 ugX kg(-1). Fifty percent maximal response corresponded to 6.1 ug X kg(-1), and 95% maximal response corresponded to 11.1 ug X kg(-1) . None of the patients had nonsinus rhythm after glycopyrrolate injection. Except for glycopyrrolate given at 4 ug x kg(-1), the systolic blood pressure increased significantly after all other doses. Glycopyrrolate in doses greater than or equal to 6 ug X kg(-1) increased the heart rate and systolic blood pressure in children anesthetized with halothane and nitrous oxide.

Keyword

Anesthesia; pediatric; Heart rate; Anesthetics; halothane; nitrous oxide; Anticholinergic drugs; glycopyrrolate

MeSH Terms

Anesthesia
Anesthetics
Blood Pressure
Child*
Glycopyrrolate
Halothane*
Heart Rate*
Heart*
Humans
Nitrous Oxide*
Oxygen
Anesthetics
Glycopyrrolate
Halothane
Nitrous Oxide
Oxygen