Korean J Anesthesiol.
1972 Dec;5(2):113-120. 10.4097/kjae.1972.5.2.113.
An Experimental Study on the Vasopressor Effects of Various Sympathomimetic Amines in Reserpinized Dogs during Nâ‚‚O-Oâ‚‚-Halothane Anesthesia
- Affiliations
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- 1Department of Anesthesiology, Seoul National University, College of Medicine, Seoul, Korea.
- KMID: 2383193
- DOI: http://doi.org/10.4097/kjae.1972.5.2.113
Abstract
- Vasopressor effects of epinephrine, norepinephrine, ephedrine, phenylephrine, methoxamine and of mephentermine were compared in resrpinized dogs with or without nitrous oxide-oxygen-halothane anesthesia. The results are as follows: (1) Epinephrine and norepinephrine were shown to have the most potent pressor effect in reserpinized and nitrous oxide-oxygen-halothane-anesthetized dogs. Phenylephrine, methoxamine, mephen-termine and ephedrine were less potent in decreasing order. (2) Decrease in mean arterial pressure was less marked in dogs reserpinized and anesthetized with nitrous oxide-oxygen-halothane than in reserpinized but unanesthetized dogs. (3) It revealed that nitrous oxide-oxygen-halothane anesthesia potentiated the vasopressor effects of the sympathomimetic amines studied. Nitrous oxide-oxygen-halothane anesthesia is implicated to exert an sympathomimetic effect.
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