Korean J Anesthesiol.  2007 Jul;53(1):145-149. 10.4097/kjae.2007.53.1.145.

Delayed Recovery of Neuromuscular Blockade by Rocuronium in a Patient with Charcot-Marie-Tooth Disease: Case reports

• Cheong YK
• Lee C
• Son Y
• Song YK
• Kim TY
• Kim DJ
• O S

• KMID: 2238315
• DOI: http://doi.org/10.4097/kjae.2007.53.1.145

Abstract

Charcot-Marie-Tooth disease, which is also known as hereditary motor and sensory neuropathy, is a heterogenous group of inherited diseases of the peripheral nerve. The spectrum of severity varies from asymptomatic individuals to those with severe limb abnormalities requiring corrective surgery. We report two brothers who had previously been diagnosed with Charcot-Marie- Tooth disease 3 years earlier and were scheduled to undergo a correction osteotomy of both feet under general anesthesia. General anesthesia was induced with propofol 2 mg/kg, rocuronium 0.8 mg/kg and was maintained with O2-N2O-Sevoflurane. The younger brother showed no delay in recovery of the neuromuscular blockade but the elder brother showed a delay.

Keyword

Charcot-Marie-Tooth disease; neuropathy; rocuronium

MeSH Terms

Anesthesia, General
Charcot-Marie-Tooth Disease*
Extremities
Foot
Hereditary Sensory and Motor Neuropathy
Humans
Neuromuscular Blockade*
Osteotomy
Peripheral Nerves
Propofol
Siblings
Tooth Diseases
Propofol