Korean J Anesthesiol.  2014 Jun;66(6):462-466. 10.4097/kjae.2014.66.6.462.

Systemic capillary leak syndrome under general anesthesia: a case report

• Jeong EK
• Kim YK
• Kim SH
• Lee CH
• Kim JS

• KMID: 2237952
• DOI: http://doi.org/10.4097/kjae.2014.66.6.462

Abstract

Systemic capillary leak syndrome (SCLS) is very rare and lethal disease and only 150 cases have been reported after the first publication of its report in 1960 by Clarkson. SCLS is characterized by hemoconcentation and hypoalbuminemia caused by reversible plasma extravasation. Its mechanism is unknown, but transient dysfunction of the endothelium is the most suspected cause and trigger of this event may cause immunologic disarrangement. After recovery of endothelial function, fluid injected during the shock period is redistributed and can cause severe pulmonary edema. SCLS should be considered in patients with acute and severe hypotension with hemoconcentration and hypoalbuminemia without obvious cardiac dysfunction. Especially we should take into account the possibility of SCLS if fluid replacement does not work or the shock state is aggravated despite aggressive fluid resuscitation and vasopressor administration. SCLS itself is a very rare disease; furthermore, SCLS that develops during well-controlled surgery is even more rare. So we report this case with review of the literature.

Keyword

Capillary leak syndrome; Hypoalbuminemia; Hypotension; Plasma extravasation

MeSH Terms

Anesthesia, General*
Capillary Leak Syndrome*
Endothelium
Humans
Hypoalbuminemia
Hypotension
Plasma
Publications
Pulmonary Edema
Rare Diseases
Resuscitation
Shock