Korean J Anesthesiol.  1997 Jun;32(6):996-1002. 10.4097/kjae.1997.32.6.996.

The Effects of Ondansetron on the Analgesic and Side Effects of Intrathecal Morphine

• Sim JY
• Lee SY
• Choi IC

• KMID: 2237766
• DOI: http://doi.org/10.4097/kjae.1997.32.6.996

Abstract

BACKGROUND
Intrathecal morphine provides good pain relief after anorectal surgery, but often associated with unpleasant side effects. Ondansetron, a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist, have been introduced for the prevention and treatment of emesis after chemotherapy in cancer patients and after general anesthesia.
METHODS
Thus we studied the effect of ondansetron on the postoperative analgesic and side effects of spinal morphine in 60 patiens. The patients were given subarachnoid injection of 0.5% tetracaine 5 mg mixed with morphine 0.3 mg and positioned to jack-knife after fixation of anesthetic level. Either simple 5% dextrose solution 1000 ml or dextrose solution 1000 ml mixed with ondansetron 8 mg was injected intravenously in a rate of 100 ml/hr. The visual analog scale (VAS) of pain and incidence and severity of postoperative nausea, vomiting, pruritus and urinary retention were evaluated at 12 hour, 24 hour and 48 hour after injection of spinal morphine.
RESULTS
The number of patients who became nauseated or vomited did not differ significantly between groups. Also, the VAS and the incidence and severity of other side effects such as pruritus and urinary retention did not differ significantly between groups.
CONCLUSION
Ondansetron administered intravenously, did not prevent side effects of intrathecal morphine.

Keyword

Analgesics; spinal; morphine; Antagonist; serotonin; ondansetron

MeSH Terms

Analgesics
Anesthesia, General
Drug Therapy
Glucose
Humans
Incidence
Morphine*
Ondansetron*
Postoperative Nausea and Vomiting
Pruritus
Serotonin
Tetracaine
Urinary Retention
Visual Analog Scale
Vomiting
Analgesics
Glucose
Morphine
Ondansetron
Serotonin
Tetracaine