Korean J Anesthesiol.  1990 Dec;23(6):938-945. 10.4097/kjae.1990.23.6.938.

Cardiovascular Changes by Endotrcheal Intubation According to Fentanyl-Diazepam Dosage

• Choi KH
• Lee JE
• Choi SJ

• KMID: 2237149
• DOI: http://doi.org/10.4097/kjae.1990.23.6.938

Abstract

Induction of general anesthesia with tracheal intubation is a routine procedure, but it can result in significant tachycardia, hypertension, and arrhythmia. Many approaches have been tried to blunt these circulatory responses. We selected randomly 45 adult patients undergoing elective surgery at Chungnam National University Hospital. They were divided into three groups. Group I: Thiopental 5 mg/kg (n=15) Group II: Fentanyl 3ug/kg+Thiopental 4mg/kg (n=15) Goup lII: Diazepam 0.1 mg/kg+Fentanyl 10ug/kg+Thiopental 2 mg/kg (n=15) Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were measured for 5 min after intubation. The results were as follow. Group I-intubation caused a significant rise in SBP, DBP, MAP, HR, (p<0.01) but each parameter except H.R, returned to normal within 5 min. Group II-intubation caused a significant rise in SBP, DBP, MAP, HR (p< 0.01), but each parameter returned to normal within 3 min. Group III-after intubation caused little cardiovascular change, but decreases significantly preintubation (p<0.01) It is concluded that diazepam and moderate dose of fentanyl can effectively prevent postintubation hypertension and tachycardia.

Keyword

Fentanyl; Diazepam; Endotracheal intubation

MeSH Terms

Adult
Anesthesia, General
Arrhythmias, Cardiac
Arterial Pressure
Blood Pressure
Chungcheongnam-do
Diazepam
Fentanyl
Heart Rate
Humans
Hypertension
Intubation*
Intubation, Intratracheal
Tachycardia
Thiopental
Diazepam
Fentanyl
Thiopental