Korean J Anesthesiol.  1994 Oct;27(10):1271-1280. 10.4097/kjae.1994.27.10.1271.

A Dose-Response Effects of Oral Clonidine on Cardiovascular System and Sedative Action

• Park BS
• Jeong JC
• Kim JH
• Kang HS
• Park TI

• KMID: 2240497
• DOI: http://doi.org/10.4097/kjae.1994.27.10.1271

Abstract

Clonidine, an 2 agonist, has been shown to be effective as preanesthetic medication in adults. To evaluate the effects of clonidine on the sedation and cardiovascular changes induced by intubation, we administered clonidine (2.0-2.5g/kg, 4.5-5.0g/kg, peros) 90-120min before induction of anesthesia. We measured heart rate, systolic pressure and diastolic pressure before premedication, before induction, after intubation and 5, 10, 15, 20 and 30 min after intubation and evaiuated sedative sction before induction. The results are as follows: 1) Before intubation heart rate decreased significantly in both clonidine groups compared with diazepam group (P<0.05). 2) Before intubation clonidine 4.5-5.0g/kg group produced a significant reduction in systolic pressure compared with diazepam group (P<0.05). 3) After intubation systolic and diastolic blood pressure increased in all group but the increasing rate was significently less then in clonidine 4.5-5.0g/kg group (P<0.05). 4) After intubstion the increase in heart rate in both clonidine groups were significsntly less than in diazepam group (P<0.005). 5) Sedative actions were not significantly different in all groups.

Keyword

Oral clonidine; Sedation; Cardiovascular system; Intubation

MeSH Terms

Adult
Anesthesia
Blood Pressure
Cardiovascular System*
Clonidine*
Diazepam
Heart Rate
Humans
Intubation
Preanesthetic Medication
Premedication
Clonidine
Diazepam