Korean J Anesthesiol.  1991 Oct;24(5):979-985. 10.4097/kjae.1991.24.5.979.

The Effect of Neostigmine Pretreatment on Vecuronium Induced Neuromuscular Blockade

• Shin BH
• Lim SH
• Choi YS
• Yoon SM
• Lee IO
• Kim NS
• Kim BG

• KMID: 2237097
• DOI: http://doi.org/10.4097/kjae.1991.24.5.979

Abstract

Prolonged neuromuscular blockade following succinylcholine may be seen when anticho- linesterase had been administered prior to reverse nondepolarizing muscle relaxant-induced paralysis, possibly anticholinesterase has been reported to inhibit serum cholinesterase activity. Our study was undertaken in order to understand the effect of a nondepolarizing muscle relaxant (vecuronium) following neostigmine pretreatment. In this study, we assessed the effect of vecuronium induced neuromuscular blockade using a train of four, 2 Hz stimulations on ulnar nerve. Patients admitted to our hospital for elective operations were divided into two groups, each group consisting of 16 patients. In group I, vecuronium 0.1 mg/kg was .administered according to the priming principle following normal saline, in group II, vecuronium 1.0mg/kg was administered according to the priming principle following neostigmine 0.05 mg/kg and glycopyrrolate 0.003 mg/kg pretreatment. Then the time for Tl to reach 5% or less(second), and the time for Tl to reach from 25% to 75%(recovery index) were measured in both groups. The time for Tl to reach 5% or less in group I(92.8+/-14.72 second) and group II(97.5+/-16.43 seconds) were not siginificant. However the recovery indexof group I(10.2 5+/-1.93 minute) and group II(8.5+/-1.80 minute) showed significant shortening in group II(p<0. 05)

Keyword

Anticholinesterase-neostigmine; Nondepolarizing muscle relaxant-vecuronium; Serum cholinesterase; Priming principle; Glycopyrrolate; TOF- T1; Recovery index

MeSH Terms

Cholinesterases
Glycopyrrolate
Humans
Neostigmine*
Neuromuscular Blockade*
Paralysis
Succinylcholine
Ulnar Nerve
Vecuronium Bromide*
Cholinesterases
Glycopyrrolate
Neostigmine
Succinylcholine
Vecuronium Bromide