Korean J Anesthesiol.  1991 Feb;24(1):139-142. 10.4097/kjae.1991.24.1.139.

The Effect of Recovery from Vecuronium following Neostigmine Administration in Children and Adult during Halothane Anesthesia

• Oh BH
• Kwak HS

• KMID: 2239382
• DOI: http://doi.org/10.4097/kjae.1991.24.1.139

Abstract

To determine Whether neoatigmine had different effecta in pediatric patients and adults during vecuronium neuromuscalar blockade, the rate of recovery following neostigmine admimistration was compared in children (n=10, group I) and adulta (n=10, group II) during nitrous oxide-Halothane anesthesia. After induction of anesthesia, patients received 100 ug/kg of vecuronium. Reversal was attempted at 10% spontaneous recovery of twitdi height, Neostigmine (30 ug/kg in children, 40 ug/kg in adults) was injected in a single bolus dose. During the first few minutes following neostigmine admimistration, no differences were obaerved between the two groups, Ten minutes after neostigmine admmistration, the first twitch (mean+/-SD) reached 95+/-2%, 93+/-2% of control value in children and adults respectively. The more complete recovery of the eighth minutes in children could be due to the faster rate of spontaneous recovery from vercuronium induced neuromuscular blockade in children.

Keyword

Neuromusular blocker-vecuronium; Neuromusular reversal-neostigmine

MeSH Terms

Adult*
Anesthesia*
Child*
Halothane*
Humans
Neostigmine*
Neuromuscular Blockade
Vecuronium Bromide*
Halothane
Neostigmine
Vecuronium Bromide